Research →  MION2

MION2

Clean, precise ionization at high pressure.
‣ Pure ions: Injects only ions, not contamination
‍
‣ Rapid  switching: Reagent changes in under a second
‍
‣ Exclusive tech: World’s only source of X-ray desorbed reagent
Request a demo

MION2 Advantages:

⬩Instant polarity switching
Rapidly change ionization conditions (in under a second) for precise chemical ionization.

⬩Pure reagent injection
Exclusively charged reagent ions enter the mixing region, eliminating sample contamination by neutrals.
‍
⬩Flexible ion selection
Broad range of reagent ions available
(e.g., Br⁻, NO₃⁻, I⁻, CH₅N₂O⁺, NH₄⁺).
⬩No fragmentation
Preserves molecular structures fully intact, significantly outperforming conventional "soft" techniques.

⬩Ultra-sensitive at ambient pressure
Achieve ultra-low (sub-ppt) detection limits for polar compounds without dilution.

⬩Ambient ion sampling capability
Easily capture background ions by simply switching voltages off.

Our ions and their super powers

Nitrate NO3-
‣ Solid Source available
Ideal for acids, HOMs, and organonitrates.
Bromide Br-
Most suited for OOMs, small acids, iodine species, HO₂ radicals.
Uronium CH₅N₂O⁺
‣ Solid Source available
Superior detection of amines, aprotic solvents, and DMSO/DMSO₂—exclusive reagent pioneered by our group.

Resources

Nature: Study of new particle formation from isoprene using MION

A December 2024 Nature study reveals how isoprene emissions drive new particle formation in the upper troposphere. A MION2-CIMS provided key measurements, detecting species critical to nucleation and growth under extreme conditions.
Read more

Analytical Chemistry: Introducing Multi-Pressure Chemical Ionization Mass Spectrometry

MPCIMS enables simultaneous detection of Volatile Organic Compounds and their oxidized reaction products within a single gas stream.
Read more

Analytical Chemistry: Fast Polarity Switching of Chemical Ionization Orbitrap MS

The polarity switching MION-Orbitrap system is shown to be a versatile and powerful technique for the online analysis of a wide range of reactive trace species.
Read more

AMT: Multiphysical description of chemical ionisation in MION2

A detailed comparison of two atmospheric pressure interface CIMS inlets: the MION2 inlet and the Eisele type inlet.
Read more
View all resources

News

Karsa Enters Chinese Market with Demo Site Installation at Fudan University

18.7.2025
Research
We are excited to announce that Karsa Ltd has entered into a Demo Site Agreement with Fudan University, marking another step forward in expanding access to our Multi-Pressure Chemical Ionization technology to customers in China.
Read more

Upcoming Webinar: Harnessing MPCI with Solid-State Reagents

13.6.2025
Research
We’re excited to invite you to a 45-minute live webinar on July 2, 2025, where our lead developers will showcase the latest advances in Multi-Pressure Chemical Ionization (MPCI) using all-solid-state reagent for nitrate (NO₃⁻), uronium (from urea), and fluoranthene.
Read more

Karsa Presenting at ASMS 2025 in Baltimore

28.5.2025
Research
Karsa will be attending the ASMS Conference on Mass Spectrometry and Allied Topics in Baltimore, June 1–5, 2025. Our team will present new developments in chemical ionization mass spectrometry, including novel reagents, instrumentation, and application workflows.
Read more
View all news

Interested in working with us?

See career opportunities