Research →  MION2

MION2

Clean, precise ionization at high pressure.
‣ Pure ions: Injects only ions, not contamination
‍
‣ Rapid  switching: Reagent changes in under a second
‍
‣ Exclusive tech: World’s only source of X-ray desorbed reagent
Request a demo

MION2 Advantages:

⬩Instant polarity switching
Rapidly change ionization conditions (in under a second) for precise chemical ionization.

⬩Pure reagent injection
Exclusively charged reagent ions enter the mixing region, eliminating sample contamination by neutrals.
‍
⬩Flexible ion selection
Broad range of reagent ions available
(e.g., Br⁻, NO₃⁻, I⁻, CH₅N₂O⁺, NH₄⁺).
⬩No fragmentation
Preserves molecular structures fully intact, significantly outperforming conventional "soft" techniques.

⬩Ultra-sensitive at ambient pressure
Achieve ultra-low (sub-ppt) detection limits for polar compounds without dilution.

⬩Ambient ion sampling capability
Easily capture background ions by simply switching voltages off.

Our ions and their super powers

Nitrate NO3-
‣ Solid Source available
Ideal for acids, HOMs, and organonitrates.
Bromide Br-
Most suited for OOMs, small acids, iodine species, HO₂ radicals.
Uronium CH₅N₂O⁺
‣ Solid Source available
Superior detection of amines, aprotic solvents, and DMSO/DMSO₂—exclusive reagent pioneered by our group.

Resources

Nature: Study of new particle formation from isoprene using MION

A December 2024 Nature study reveals how isoprene emissions drive new particle formation in the upper troposphere. A MION2-CIMS provided key measurements, detecting species critical to nucleation and growth under extreme conditions.
Read more

Analytical Chemistry: Introducing Multi-Pressure Chemical Ionization Mass Spectrometry

MPCIMS enables simultaneous detection of Volatile Organic Compounds and their oxidized reaction products within a single gas stream.
Read more

Analytical Chemistry: Fast Polarity Switching of Chemical Ionization Orbitrap MS

The polarity switching MION-Orbitrap system is shown to be a versatile and powerful technique for the online analysis of a wide range of reactive trace species.
Read more

AMT: Multiphysical description of chemical ionisation in MION2

A detailed comparison of two atmospheric pressure interface CIMS inlets: the MION2 inlet and the Eisele type inlet.
Read more
View all resources

News

Karsa unveils ORBION: a pan‑molecular air analyzer

3.9.2025
Research
University of Helsinki team to deploy ORBION at CERN’s CLOUD chamber to map atmospheric chemistry in real-time.
Read more

Karsa Showcases Ionization Innovations at EAC 2025 in Lecce

1.9.2025
Research
Karsa is attending the European Aerosol Conference 2025 in Lecce, Italy, where we are presenting new developments in High Resolution Chemical Ionization Mass Spectrometry for aerosol research—and hosting a user get-together to connect with the MION Orbitrap community.
Read more

Karsa at ICNAA 2025: Sponsoring and Presenting High-Resolution MPCIMS

20.8.2025
Research
Karsa is proud to be sponsoring and attending the 22nd International Conference on Nucleation and Atmospheric Aerosols (ICNAA 2025) in Vienna, Austria (August 24–29, 2025). Fariba Partovi will share our recent work on high-mass-resolution MPCIMS with uronium for comprehensive trace gas detection.
Read more
View all news

Interested in working with us?

See career opportunities