Research →  MION2

MION2

Clean, precise ionization at high pressure.
‣ Pure ions: Injects only ions, not contamination
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‣ Rapid  switching: Reagent changes in under a second
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‣ Exclusive tech: World’s only source of X-ray desorbed reagent
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MION2 Advantages:

⬩Instant polarity switching
Rapidly change ionization conditions (in under a second) for precise chemical ionization.

⬩Pure reagent injection
Exclusively charged reagent ions enter the mixing region, eliminating sample contamination by neutrals.
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⬩Flexible ion selection
Broad range of reagent ions available
(e.g., Br⁻, NO₃⁻, I⁻, CH₅N₂O⁺, NH₄⁺).
⬩No fragmentation
Preserves molecular structures fully intact, significantly outperforming conventional "soft" techniques.

⬩Ultra-sensitive at ambient pressure
Achieve ultra-low (sub-ppt) detection limits for polar compounds without dilution.

⬩Ambient ion sampling capability
Easily capture background ions by simply switching voltages off.

Our ions and their super powers

Nitrate NO3-
‣ Solid Source available
Ideal for acids, HOMs, and organonitrates.
Bromide Br-
Most suited for OOMs, small acids, iodine species, HO₂ radicals.
Uronium CH₅N₂O⁺
‣ Solid Source available
Superior detection of amines, aprotic solvents, and DMSO/DMSO₂—exclusive reagent pioneered by our group.

Resources

Application Note: Rapid, Ultra sensitive Detection of Atmospheric Organonitrates

Organonitrates play a pivotal role in atmospheric chemistry: they regulate the NOₓ budget, drive secondary organic aerosol formation, and act as reservoirs for long-range nitrogen transport. Measuring these compounds at ultra-trace levels in humid, chemically complex air remains a significant analytical challenge.
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Nature: Study of new particle formation from isoprene using MION

A December 2024 Nature study reveals how isoprene emissions drive new particle formation in the upper troposphere. A MION2-CIMS provided key measurements, detecting species critical to nucleation and growth under extreme conditions.
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Analytical Chemistry: Introducing Multi-Pressure Chemical Ionization Mass Spectrometry

MPCIMS enables simultaneous detection of Volatile Organic Compounds and their oxidized reaction products within a single gas stream.
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Analytical Chemistry: Fast Polarity Switching of Chemical Ionization Orbitrap MS

The polarity switching MION-Orbitrap system is shown to be a versatile and powerful technique for the online analysis of a wide range of reactive trace species.
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News

Orbion Launch Webinar: Environmental Air Analysis with an Integrated HR-MPCIMS Platform

5.11.2025
Research
On 20 November 2025, Karsa will host an online webinar introducing Orbion, the fully integrated High-Resolution Multi-Pressure Chemical Ionization (HR-MPCI) mass spectrometer platform for air analysis. Two live sessions will be held to accommodate different regions: 09:00 (EET) and 17:00 (EET).
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Orbion Launch: Website Updated and Brochure Now Live

30.10.2025
Research
Today we are formally launching Orbion, the fully integrated High Resolution Multi-Pressure Chemical Ionization (HR-MPCI) mass spectrometer platform for air analysis. Orbion combines high-resolution detection, broad chemical coverage, and field-ready operation in a single cohesive system. The brochure is now available to download.
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Karsa unveils ORBION: a pan‑molecular air analyzer

3.9.2025
Research
University of Helsinki team to deploy ORBION at CERN’s CLOUD chamber to map atmospheric chemistry in real-time.
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